Fostering Access to PrEP Among Adolescent Girls and Young Women Aged 16 to 24 Years at High Risk of HIV Through the DREAMS Initiative in Four Districts in Zambia.

IF 1.6 4区医学 Q2 EDUCATION & EDUCATIONAL RESEARCH

Aids Education and Prevention Pub Date : 2023-07-01 DOI:10.1521/aeap.2023.35.suppA.52

Julian Chipukuma, Brianna Lindsay, Linah K Mwango, Pawel Olowski, Caitlin Baumhart, Kalima Tembo, Adebayo A Olufunso, Christine Bwale, Priscilla Makasa, Monde Muchoka, Salina Tembo, Waitolo Mbokile, Comfort Panda, Siphiwe Malupande, Richard Lubinda, Brenda Bwembelo, Everess Fundulu, Chimpinde Munsongo, Kelvin Watala, Bupe Musonda, Omega Chituwo, Jackson Okuku, Annie Mwila, Carlos Muleya, Pragna Patel, Cassidy W Claassen

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引用次数: 0

Abstract

Adolescent girls and young women (AGYW) in sub-Saharan Africa remain at high risk for HIV, yet limited data exist on implementation of HIV pre-exposure prophylaxis (PrEP) for this group. We examined PrEP uptake among AGYW using a retrospective cohort enrolled in the Determined Resilient Empowered AIDS-free Mentored Safe (DREAMS) initiative in Zambia between October 2020 and March 2022. Consent was obtained from eligible AGYW at substantial risk for HIV, and they voluntarily participated in PrEP. Multivariable logistic regression was used to examine factors associated with PrEP refills following initiation. Of 4,162 HIV-negative AGYW, 3,233 (77%) were at substantial risk and initiated on PrEP. Overall, 68% of AGYW had at least one refill, but this differed significantly by age group and district. DREAMS was successful at reaching AGYW with PrEP services. More evidence is needed to assess reasons for discontinuation and to improve persistence for those with sustained HIV risk.

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通过赞比亚四个地区的 DREAMS 计划，促进 16-24 岁艾滋病高危少女和年轻女性获得 PrEP。

撒哈拉以南非洲地区的少女和年轻女性（AGYW）仍然是艾滋病的高危人群，但针对这一群体实施艾滋病暴露前预防（PrEP）的数据却十分有限。我们利用 2020 年 10 月至 2022 年 3 月期间在赞比亚参加 "有决心、有能力、无艾滋病、有指导、安全"（DREAMS）计划的回顾性队列，研究了 AGYW 对 PrEP 的接受情况。我们征得了符合条件的高危艾滋病女青年的同意，她们自愿参加了 PrEP。多变量逻辑回归用于研究与 PrEP 启动后重新填写相关的因素。在 4,162 名 HIV 阴性的 AGYW 中，3,233 人（77%）属于高危人群并开始接受 PrEP 治疗。总体而言，68% 的女性艾滋病患者至少补服过一次，但不同年龄组和地区的情况差异很大。DREAMS 成功地为 AGYW 提供了 PrEP 服务。还需要更多的证据来评估中断服务的原因，并提高那些有持续感染艾滋病毒风险的人的坚持率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Aids Education and Prevention Multiple-

CiteScore

2.20

自引率

5.60%

发文量

期刊介绍： Presenting state-of-the-art research and information, AIDS Education and Prevention is a vital addition to the library collections of medical schools, hospitals, and other institutions and organizations with HIV/AIDS research programs. The journal integrates public health, psychosocial, sociocultural, and public policy perspectives on issues of key concern nationally and globally.