Reduced ADAMTS13 activity and high D-dimer levels are associated with thrombosis in patients with systemic lupus erythematosus.

IF 1.2 4区医学 Q4 HEMATOLOGY

Blood Coagulation & Fibrinolysis Pub Date : 2023-10-01 Epub Date: 2023-08-02 DOI:10.1097/MBC.0000000000001247

Tipparat Penglong, Anuchit Boontanvansom, Pongtep Viboonjuntra, Boonjing Siripaitoon

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引用次数: 0

Abstract

Introduction: Patients with systemic lupus erythematosus (SLE) have an increased risk of vascular thrombosis compared to the general population. Therefore, biomarkers for predicting the risk of thrombosis in patients with SLE are needed.

Methods: In the present study, a total of 66 patients with SLE (22 with and 44 without a history of thrombosis) were enrolled. The cases with thrombosis and the controls without thrombosis were matched for age (± 5 years) and sex. We assessed ADAMTS13 activity, D-dimer levels, and antiphospholipid antibodies. Clinical manifestations, SLE disease activity, classical risk factors, and medical history were collected.

Results: ADAMTS13 activity was significantly reduced, and D-dimer levels were significantly increased in patients with SLE with a history of thrombosis compared with those in patients without thrombosis. Receiver operating characteristic curve analysis revealed a good correlation between reduced ADAMTS13 activity and a history of thrombosis. Reduced ADAMTS13 activity was correlated with increased D-dimer levels only in the thrombotic group.

Conclusion: Reduced ADAMTS13 activity and high D-dimer levels are associated with thrombosis and may serve as prognostic markers for thrombosis in patients with SLE.

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ADAMTS13活性降低和D-二聚体水平升高与系统性红斑狼疮患者血栓形成有关。

引言：与普通人群相比，系统性红斑狼疮（SLE）患者发生血管血栓的风险增加。因此，需要预测SLE患者血栓形成风险的生物标志物。方法：本研究共纳入66例SLE患者（22例有血栓病史，44例无血栓病史）。有血栓形成的病例和没有血栓形成的对照组的年龄匹配（±5 年龄）和性别。我们评估了ADAMTS13活性、D-二聚体水平和抗磷脂抗体。收集临床表现、SLE疾病活动性、典型危险因素和病史。结果：有血栓病史的SLE患者与无血栓病史的患者相比，ADAMTS13活性显著降低，D-二聚体水平显著升高。受试者操作特征曲线分析显示ADAMTS13活性降低与血栓形成史之间存在良好相关性。ADAMTS13活性的降低仅与血栓形成组中D-二聚体水平的升高相关。结论：ADAMTS13活性降低和D-二聚体水平升高与系统性红斑狼疮患者血栓形成有关，可作为SLE患者血栓形成的预后标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Blood Coagulation & Fibrinolysis 医学-血液学

CiteScore

1.90

自引率

0.00%

发文量

111

审稿时长

4-8 weeks

期刊介绍： Blood Coagulation & Fibrinolysis is an international fully refereed journal that features review and original research articles on all clinical, laboratory and experimental aspects of haemostasis and thrombosis. The journal is devoted to publishing significant developments worldwide in the field of blood coagulation, fibrinolysis, thrombosis, platelets and the kininogen-kinin system, as well as dealing with those aspects of blood rheology relevant to haemostasis and the effects of drugs on haemostatic components