Use of Biologics and Stem Cells in the Treatment of Other Inflammatory Diseases in the Horse

IF 1.1 3区 农林科学 Q3 VETERINARY SCIENCES
Jennifer G. Barrett PhD, DVM, DACVS, DACVSMR, Elizabeth S. MacDonald BVMS, MS, DACVIM
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引用次数: 1
生物制品和干细胞在治疗马的其他炎症性疾病中的应用。
间充质干细胞是一种强大的免疫调节细胞,通过多种机制协调、抑制和控制免疫系统的细胞。MSCs通过(1)细胞因子、生长因子和信号分子作为身体各种受损或退化细胞的救星;(2) 细胞外囊泡(外泌体)信号传导;(3)线粒体的直接捐献。几项评估MSC疗效的研究使用了使用异种培养基生长的MSC,这可能会降低或消除疗效。尽管还需要更多的研究来优化MSC的抗炎潜力,但有充分的证据表明MSC疗法值得进一步开发。
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来源期刊
CiteScore
2.10
自引率
9.10%
发文量
55
审稿时长
>36 weeks
期刊介绍: Veterinary Clinics of North America: Equine Practice presents those in the veterinary medicine field with the most current treatment of horses, updates on the latest advances, and provides a sound basis for choosing treatment options. Published 3 times a year—in April, August, and December—each issue features expert, state-of-the-art reviews on a single topic in equine practice, including gastroenterology, imaging, infectious diseases, nutrition, orthopedics, pathology, pharmacology and therapeutics, and surgery.
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