Effect of Low-Concentration Atropine Eye Drops in Controlling the Progression of Myopia in Children: A One- and Two-Year Follow-Up Study.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-06-01 Epub Date: 2023-08-01 DOI:10.1080/09286586.2023.2232462

Hongbo Zhang, Peihua Yang, Yahong Li, Weixiao Zhang, Shumao Li

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引用次数: 0

Abstract

Purpose: Atropine eye drops have been shown to slow the progression of myopia, but there has been limited research on the effectiveness of 0.05% atropine in treating myopia. This study aimed to investigate the safety and efficacy of 0.05% atropine eye drops in controlling myopia in children.

Methods: The study included 424 participants aged 6 to 12 years between January 1, 2015, and January 1, 2021. Of these, 213 were randomly assigned to the 0.05% atropine group and 211 to the placebo group. The cycloplegic spherical equivalent (SE), axial length (AL), corneal curvature (K), and anterior chamber depth (ACD) were measured using IOLMaster. The lens power and corneal astigmatism were also determined. The changes in ocular biometric parameters were compared between the two groups, and the contributions of ocular characteristics to SE progression were calculated and compared.

Results: Over a 12-month period, the changes in spherical equivalent were -0.03 ± 0.28 and -0.32 ± 0.14 in the atropine and placebo groups, respectively (P = .01). The changes in axial length were 0.06 ± 0.11 and 0.17 ± 0.12, respectively (P = .01). At 18 and 24 months, there were significant differences in axial length and spherical equivalent between the atropine and placebo groups. Multiple regression models accounting for changes in AL, K, and lens magnification explained 87.23% and 98.32% of SE changes in the atropine and placebo groups, respectively. At 1 year (p = .01) and 2 years (p = .03), there were significant differences in photophobia between the atropine and placebo groups.

Conclusions: This two-year follow-up study demonstrates that 0.05% atropine eye drops are safe and effective in preventing the development of myopia in school-aged children.

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低浓度阿托品滴眼液对控制儿童近视发展的效果：一年和两年随访研究》。

目的：阿托品滴眼液已被证明可延缓近视的发展，但有关 0.05% 阿托品治疗近视效果的研究却很有限。本研究旨在探讨 0.05% 阿托品滴眼液在控制儿童近视方面的安全性和有效性：研究纳入了2015年1月1日至2021年1月1日期间年龄在6至12岁之间的424名参与者。其中，213 人被随机分配到 0.05% 阿托品组，211 人被随机分配到安慰剂组。使用 IOLMaster 测量了屈光度球面等效 (SE)、轴向长度 (AL)、角膜曲率 (K) 和前房深度 (ACD)。此外，还测定了晶状体功率和角膜散光。比较了两组患者眼部生物测量参数的变化，并计算和比较了眼部特征对 SE 进展的贡献：结果：在 12 个月的时间里，阿托品组和安慰剂组的球面等值变化分别为 -0.03 ± 0.28 和 -0.32 ± 0.14（P = .01）。轴长的变化分别为 0.06 ± 0.11 和 0.17 ± 0.12（P = 0.01）。在 18 个月和 24 个月时，阿托品组和安慰剂组的轴长和球面等值有显著差异。考虑到AL、K和晶状体放大率变化的多元回归模型分别解释了阿托品组和安慰剂组SE变化的87.23%和98.32%。在 1 年（p = 0.01）和 2 年（p = 0.03）时，阿托品组和安慰剂组在畏光程度上存在显著差异：这项为期两年的跟踪研究表明，0.05% 阿托品滴眼液能安全有效地预防学龄儿童近视的发展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.