Triglyceride-Glucose Index Cutoff Point Is an Accurate Marker for Predicting the Prevalence of Metabolic Syndrome in Obese Caucasian Subjects.

IF 3.2 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Annals of Nutrition and Metabolism Pub Date : 2023-01-01 Epub Date: 2022-10-07 DOI:10.1159/000526988

David Primo, Olatz Izaola, Daniel A de Luis

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Abstract

Background: Recently, the triglyceride-glucose (TyG) index has been suggested as a surrogate insulin resistance marker. This index could act as an early screening marker in individuals with a high risk of metabolic syndrome (MS) such as obese subjects.

Aims: The objective of this work was to detect the cutoff point of the TyG index for the diagnosis of MS according to ATPIII criteria on obese subjects and to compare with HOMA-IR.

Methods: We conducted a cross-sectional study in 1,494 obese subjects. Measurements of adiposity parameters, blood pressure, fasting blood glucose, insulin concentration, insulin resistance (HOMA-IR), lipid profile, C-reactive protein, adipokines, and the prevalence of MS were determined. The TyG index was calculated from the next equation: Ln (fasting triglycerides (mg/dL) × fasting glucose (mg/dL))/2.

Results: A total of 1,494 subjects were recruited, 421 males (28.1%) and 1,073 females (71.8%), with an average age of 45.8 ± 15.3 years (range: 29-62). A total of 677 subjects had MS (45.5%) and 817 did not show MS (54.6%). The averages of HOMA-IR and TyG index values increased as the components of MS were aggregated, and both indexes were higher in subjects with MS. The area under the curve (AUC) of the TyG index according to ATPIII criteria showed values of 0.746 (0.721-0.771; p = 0.001). The cutoff point according to the Youden index was 4.72, with sensitivity and specificity of 87% and 88.2%, respectively. For the HOMA-IR, AUC showed values of 0.682 (0.654-0.710; p = 0.01). The cutoff point was 3.23, with sensitivity and specificity of 78% and 70.1%, respectively.

Conclusions: The TyG index is more powerful for predicting MS than HOMA-IR in Caucasian obese subjects.

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甘油三酯-葡萄糖指数临界点是预测肥胖白种人代谢综合征患病率的准确标志。

背景：最近，甘油三酯-葡萄糖（TyG）指数被认为是胰岛素抵抗的替代标志物。目的：本研究的目的是根据 ATPIII 标准检测肥胖受试者诊断 MS 的 TyG 指数临界点，并与 HOMA-IR 进行比较：我们对 1494 名肥胖者进行了横断面研究。方法：我们对 1,494 名肥胖受试者进行了横断面研究，测定了脂肪参数、血压、空腹血糖、胰岛素浓度、胰岛素抵抗（HOMA-IR）、血脂概况、C 反应蛋白、脂肪因子以及 MS 患病率。TyG 指数按下式计算：Ln（空腹甘油三酯（毫克/分升）×空腹葡萄糖（毫克/分升））/2：共招募了 1,494 名受试者，其中男性 421 名（28.1%），女性 1,073 名（71.8%），平均年龄为 45.8 ± 15.3 岁（范围：29-62 岁）。共有 677 名受试者患有多发性硬化症（45.5%），817 名受试者未患有多发性硬化症（54.6%）。HOMA-IR和TyG指数的平均值随着MS成分的增加而增加，在患有MS的受试者中这两个指数都较高。根据 ATPIII 标准，TyG 指数的曲线下面积（AUC）值为 0.746（0.721-0.771；P = 0.001）。尤登指数的临界点为 4.72，敏感性和特异性分别为 87% 和 88.2%。HOMA-IR 的 AUC 值为 0.682 (0.654-0.710; p = 0.01)。截断点为 3.23，敏感性和特异性分别为 78% 和 70.1%：TyG指数比HOMA-IR更能预测白种人肥胖症。

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来源期刊

Annals of Nutrition and Metabolism 医学-内分泌学与代谢

CiteScore

6.50

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： ''Annals of Nutrition and Metabolism'' is a leading international peer-reviewed journal for sharing information on human nutrition, metabolism and related fields, covering the broad and multidisciplinary nature of science in nutrition and metabolism. As the official journal of both the International Union of Nutritional Sciences (IUNS) and the Federation of European Nutrition Societies (FENS), the journal has a high visibility among both researchers and users of research outputs, including policy makers, across Europe and around the world.