Calculation of Tissue Oxygenation via an Inverse Boundary Problem for Transcutaneous Oxygenation Wearable Applications

IF 4.6 Q1 CHEMISTRY, ANALYTICAL
Juan Pedro Cascales*, Adina E. Draghici, Helen Keshishian, J. Andrew Taylor and Conor L. Evans*, 
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引用次数: 1

Abstract

In this article, we present a toolset to fully leverage a previously developed transcutaneous oxygenation monitor (TCOM) wearable technology to accurately measure skin oxygenation values. We describe numerical models and experimental characterization techniques that allow for the extraction of precise tissue oxygenation measurements. The numerical model is based on an inverse boundary problem of the parabolic equation with Dirichlet boundary conditions. To validate this model and characterize the diffusion of oxygen through the oxygen sensing materials, we designed a series of control/calibration experiments modeled after the device’s clinical application using oxygenation values in the physiological range expected for healthy tissue. Our results demonstrate that it is possible to obtain accurate tissue pO2 measurements without the need for long equilibration times with a small wearable device.

Abstract Image

基于反边界问题的经皮氧合可穿戴应用组织氧合计算
在这篇文章中,我们提出了一个工具集,以充分利用先前开发的经皮氧合监测仪(TCOM)可穿戴技术来准确测量皮肤氧合值。我们描述了允许提取精确组织氧合测量值的数值模型和实验表征技术。该数值模型基于具有狄利克雷边界条件的抛物型方程的逆边界问题。为了验证该模型并表征氧气通过氧气传感材料的扩散,我们根据该设备的临床应用设计了一系列控制/校准实验,使用健康组织预期生理范围内的氧合值。我们的结果表明,在不需要使用小型可穿戴设备长时间平衡的情况下,可以获得准确的组织pO2测量值。
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来源期刊
ACS Measurement Science Au
ACS Measurement Science Au 化学计量学-
CiteScore
5.20
自引率
0.00%
发文量
0
期刊介绍: ACS Measurement Science Au is an open access journal that publishes experimental computational or theoretical research in all areas of chemical measurement science. Short letters comprehensive articles reviews and perspectives are welcome on topics that report on any phase of analytical operations including sampling measurement and data analysis. This includes:Chemical Reactions and SelectivityChemometrics and Data ProcessingElectrochemistryElemental and Molecular CharacterizationImagingInstrumentationMass SpectrometryMicroscale and Nanoscale systemsOmics (Genomics Proteomics Metabonomics Metabolomics and Bioinformatics)Sensors and Sensing (Biosensors Chemical Sensors Gas Sensors Intracellular Sensors Single-Molecule Sensors Cell Chips Arrays Microfluidic Devices)SeparationsSpectroscopySurface analysisPapers dealing with established methods need to offer a significantly improved original application of the method.
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