Regulation of endogenous retroviruses in murine embryonic stem cells and early embryos.

IF 5.3 2区生物学 Q2 CELL BIOLOGY

Journal of Molecular Cell Biology Pub Date : 2024-01-17 DOI:10.1093/jmcb/mjad052

Xinyi Lu

引用次数: 0

Abstract

Endogenous retroviruses (ERVs) are important components of transposable elements that constitute ∼40% of the mouse genome. ERVs exhibit dynamic expression patterns during early embryonic development and are engaged in numerous biological processes. Therefore, ERV expression must be closely monitored in cells. Most studies have focused on the regulation of ERV expression in mouse embryonic stem cells (ESCs) and during early embryonic development. This review touches on the classification, expression, and functions of ERVs in mouse ESCs and early embryos and mainly discusses ERV modulation strategies from the perspectives of transcription, epigenetic modification, nucleosome/chromatin assembly, and post-transcriptional control.

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小鼠胚胎干细胞和早期胚胎中内源性逆转录病毒的调控。

内源性逆转录病毒（ERV）是转座元件的重要组成部分，占小鼠基因组的 40%。ERV在早期胚胎发育过程中表现出动态表达模式，并参与许多生物过程。因此，必须密切监测ERV在细胞中的表达。大多数研究都集中于小鼠胚胎干细胞（ESC）和早期胚胎发育过程中ERV表达的调控。本综述涉及ERV在小鼠胚胎干细胞和早期胚胎中的分类、表达和功能，主要从转录、表观遗传修饰、核糖体/染色质组装和转录后调控等角度探讨ERV调控策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Molecular Cell Biology CELL BIOLOGY-

CiteScore

9.60

自引率

1.80%

发文量

1383

期刊介绍： The Journal of Molecular Cell Biology ( JMCB ) is a full open access, peer-reviewed online journal interested in inter-disciplinary studies at the cross-sections between molecular and cell biology as well as other disciplines of life sciences. The broad scope of JMCB reflects the merging of these life science disciplines such as stem cell research, signaling, genetics, epigenetics, genomics, development, immunology, cancer biology, molecular pathogenesis, neuroscience, and systems biology. The journal will publish primary research papers with findings of unusual significance and broad scientific interest. Review articles, letters and commentary on timely issues are also welcome. JMCB features an outstanding Editorial Board, which will serve as scientific advisors to the journal and provide strategic guidance for the development of the journal. By selecting only the best papers for publication, JMCB will provide a first rate publishing forum for scientists all over the world.