The Effect of Bisoprolol on Premature Ventricular Complex in Vietnamese Patients with Hypertension and Left Ventricular Hypertrophy.

IF 1.5 Q3 PERIPHERAL VASCULAR DISEASE

Current Hypertension Reviews Pub Date : 2023-01-01 DOI:10.2174/1573402119666230110101228

Son Kim Tran, Toan Hoang Ngo, Anh Thi Phuong Nguyen, Huyen Thi Ngoc Huynh, Cuong Tan Vo, Ngan Ngoc Bao Nguyen, Thang Hoang Nguyen, Minh Van Huynh

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引用次数: 1

Abstract

Background: Premature ventricular contraction (PVC) is a common arrhythmia that causes a large number of clinical symptoms, adversely impacts the quality of life, and can even initiate serious arrhythmias, such as ventricular tachycardia or ventricular fibrillation. The incidence of premature ventricular contraction is higher in hypertensive patients, particularly if concomitant left ventricular hypertrophy (LVH) is present.

Objectives: This study was conducted on the characteristics of PVC in hypertensive patients with left ventricular hypertrophy and aimed to evaluate the effect of bisoprolol on PVC in Vietnamese patients with hypertension and LVH.

Materials and methods: We conducted a study to determine how bisoprolol potency affected PVC management in the group with both high blood pressure and LVH. We selected a convenient sample of all patients who came to the Medical Examination Department at the Can Tho University of Medicine and Pharmacy Hospital and met sampling criteria with hypertension, LVH on echocardiography, and PVC on 12-leads electrocardiogram. Over 2 years, we collected 76 patients who satisfied the above conditions. Out of which, 50 patients were indicated for management with bisoprolol, and 26 patients were excluded from the study, including 7 patients with asthma and 19 patients who had simple PVC on a 24-hour Holter ECG. Data were analyzed with SPSS version 22.

Results: Fifty patients participated in the study, of whom 70% were female. It is clear that palpitation was the most prevalent symptom (66%), and 38% of patients had complicated PVC (Lown III-V). When treating PVC with bisoprolol, 50% of patients achieved the treatment goal with a decrease in the number of PVCs of more than 70%, accompanied by symptom relief and eradication of dangerous PVCs. After 4 weeks of treatment, bisoprolol decreased the number of PVCs, heart rate, and blood pressure while also easing PVC-related symptoms (p < 0.05).

Conclusion: Low-dose bisoprolol effectively reduces the number of PVCs in hypertensive patients with LVH.

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比索洛尔对越南高血压左心室肥厚患者早衰心室复合体的影响。

背景:室性早搏(PVC)是一种常见的心律失常，可引起大量临床症状，对生活质量产生不利影响，甚至可引发严重的心律失常，如室性心动过速或心室颤动。高血压患者室性早搏的发生率较高，尤其是伴有左心室肥厚(LVH)的患者。目的:研究高血压左室肥厚患者的PVC特点，探讨比索洛尔对越南高血压合并左室肥厚患者PVC的影响。材料和方法:我们进行了一项研究，以确定比索洛尔效力如何影响高血压和LVH组的PVC管理。我们选取了一组方便的样本，选取了所有到Can Tho University Medicine and Pharmacy Hospital医学检查科就诊并符合高血压、超声心动图LVH和12导联心电图PVC采样标准的患者。在2年多的时间里，我们收集了76例符合上述条件的患者。其中，50例患者适用比索洛尔治疗，26例患者被排除在研究之外，包括7例哮喘患者和19例24小时动态心电图显示单纯性PVC的患者。数据采用SPSS version 22进行分析。结果:50例患者参与研究，其中70%为女性。很明显，心悸是最常见的症状(66%)，38%的患者合并了PVC (low III-V)。比索洛尔治疗PVC时，50%的患者达到治疗目标，室性早搏数减少70%以上，伴有症状缓解和危险室性早搏根除。治疗4周后，比索洛尔降低了室性早搏次数、心率和血压，同时也缓解了室性早搏相关症状(p < 0.05)。结论:小剂量比索洛尔可有效降低伴有LVH的高血压患者室性早搏次数。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Hypertension Reviews PERIPHERAL VASCULAR DISEASE-

CiteScore

4.80

自引率

0.00%

发文量

期刊介绍： Current Hypertension Reviews publishes frontier reviews/ mini-reviews, original research articles and guest edited thematic issues on all the latest advances on hypertension and its related areas e.g. nephrology, clinical care, and therapy. The journal’s aim is to publish the highest quality review articles dedicated to clinical research in the field. The journal is essential reading for all clinicians and researchers in the field of hypertension.