Risk factors of systemic lupus erythematosus: an overview of systematic reviews and Mendelian randomization studies.

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS
Xin-Yu Xiao, Qian Chen, Yun-Zhou Shi, Li-Wen Li, Can Hua, Hui Zheng
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引用次数: 1

Abstract

Background: The etiology of systemic lupus erythematosus is complex and incurable. A large number of systematic reviews have studied the risk factors of it. Mendelian randomization is an analytical method that uses genetic data as tool variables to evaluate the causal relationship between exposure and outcome.

Objective: To review the systematic reviews and Mendelian randomization studies that focused on the risk factors of systemic lupus erythematosus and shed light on the development of treatments for its prevention and intervention.

Methods: From inception to January 2022, we systematically searched MEDLINE (via PubMed) and Embase for related systematic reviews and Mendelian randomization studies. Extract relevant main data for studies that meet inclusion criteria. The quality of systematic reviews was assessed by using Assessment of Multiple Systematic Reviews 2 (AMSTAR-2). Finally, the risk factors are scored comprehensively according to the results' quantity, quality, and consistency.

Results: Our study involved 64 systematic reviews and 12 Mendelian randomization studies. The results of systematic reviews showed that diseases (endometriosis, atopic dermatitis, allergic rhinitis), lifestyle (smoking, drinking, vaccination), and gene polymorphism influenced the incidence of systemic lupus erythematosus. The results of Mendelian randomization studies identified the role of disease (periodontitis, celiac disease), trace elements (selenium, iron), cytokines (growth differentiation factor 15), and gut microbiome in the pathogenesis of systemic lupus erythematosus.

Conclusion: We should pay attention to preventing and treating systemic lupus erythematosus in patients with endometriosis, celiac disease, and periodontitis. Take appropriate dietary supplements to increase serum iron and selenium levels to reduce the risk of systemic lupus erythematosus. There should be no excessive intervention in lifestyles such as smoking and drinking.

系统性红斑狼疮的危险因素:系统评价和孟德尔随机化研究综述。
背景:系统性红斑狼疮的病因复杂且无法治愈。大量的系统综述研究了其危险因素。孟德尔随机化是一种使用遗传数据作为工具变量来评估暴露与结果之间因果关系的分析方法。目的:回顾系统性红斑狼疮危险因素的系统评价和孟德尔随机化研究,为系统性红斑狼疮的预防和干预治疗提供参考。方法:从成立到2022年1月,我们系统地检索MEDLINE(通过PubMed)和Embase进行相关的系统评价和孟德尔随机化研究。提取符合纳入标准的研究的相关主要数据。采用多系统评价评价2 (AMSTAR-2)评价系统评价的质量。最后根据结果的数量、质量和一致性对风险因素进行综合评分。结果:我们的研究包括64项系统综述和12项孟德尔随机化研究。系统评价结果显示疾病(子宫内膜异位症、特应性皮炎、变应性鼻炎)、生活方式(吸烟、饮酒、接种疫苗)和基因多态性影响系统性红斑狼疮的发病率。孟德尔随机化研究的结果确定了疾病(牙周炎、乳糜泻)、微量元素(硒、铁)、细胞因子(生长分化因子15)和肠道微生物群在系统性红斑狼疮发病机制中的作用。结论:子宫内膜异位症、乳糜泻、牙周炎患者并发系统性红斑狼疮应重视预防和治疗。服用适当的膳食补充剂,增加血清铁和硒水平,以降低系统性红斑狼疮的风险。不应该过度干预吸烟和饮酒等生活方式。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
ACS Applied Bio Materials
ACS Applied Bio Materials Chemistry-Chemistry (all)
CiteScore
9.40
自引率
2.10%
发文量
464
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