Mesenchymal stem cell-derived exosomes and skin photoaging: From basic research to practical application.

IF 2.5 4区医学 Q2 DERMATOLOGY

Photodermatology, photoimmunology & photomedicine Pub Date : 2023-11-01 Epub Date: 2023-08-21 DOI:10.1111/phpp.12910

Yihao Wang, Xu Shen, Shenghua Song, Yan Chen, Yiping Wang, Junlin Liao, Nian Chen, Li Zeng

{"title":"Mesenchymal stem cell-derived exosomes and skin photoaging: From basic research to practical application.","authors":"Yihao Wang, Xu Shen, Shenghua Song, Yan Chen, Yiping Wang, Junlin Liao, Nian Chen, Li Zeng","doi":"10.1111/phpp.12910","DOIUrl":null,"url":null,"abstract":"Background: Skin photoaging is a condition caused by long-term exposure to ultraviolet irradiation, resulting in a variety of changes in the skin, such as capillary dilation, increased or absent pigmentation, dryness, sagging, and wrinkles. Stem cells possess a remarkable antioxidant capacity and the ability to proliferate, differentiate, and migrate, and their main mode of action is through paracrine secretion, with exosomes being the primary form of secretion. Stem cell-derived exosomes contain a variety of growth factors and cytokines and may have great potential to promote skin repair and delay skin ageing.Methods: This review focuses on the mechanisms of UV-induced skin photoaging, the research progress of stem cell exosomes against skin photoaging, emerging application approaches and limitations in the application of exosome therapy.Result: Exosomes derived from various stem cells have the potential to prevent skin photoaging.Conclusion: The combination with novel materials may be a key step for their practical application, which could be an important direction for future basic research and practical applications.","PeriodicalId":20123,"journal":{"name":"Photodermatology, photoimmunology & photomedicine","volume":null,"pages":null},"PeriodicalIF":2.5000,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Photodermatology, photoimmunology & photomedicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1111/phpp.12910","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/8/21 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"DERMATOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Skin photoaging is a condition caused by long-term exposure to ultraviolet irradiation, resulting in a variety of changes in the skin, such as capillary dilation, increased or absent pigmentation, dryness, sagging, and wrinkles. Stem cells possess a remarkable antioxidant capacity and the ability to proliferate, differentiate, and migrate, and their main mode of action is through paracrine secretion, with exosomes being the primary form of secretion. Stem cell-derived exosomes contain a variety of growth factors and cytokines and may have great potential to promote skin repair and delay skin ageing.

Methods: This review focuses on the mechanisms of UV-induced skin photoaging, the research progress of stem cell exosomes against skin photoaging, emerging application approaches and limitations in the application of exosome therapy.

Result: Exosomes derived from various stem cells have the potential to prevent skin photoaging.

Conclusion: The combination with novel materials may be a key step for their practical application, which could be an important direction for future basic research and practical applications.

查看原文本刊更多论文

间充质干细胞衍生外泌体与皮肤光老化:从基础研究到实际应用。

背景:皮肤光老化是由于长期暴露在紫外线照射下引起的一种状况，导致皮肤的各种变化，如毛细血管扩张，色素沉着增加或消失，干燥，下垂和皱纹。干细胞具有显著的抗氧化能力和增殖、分化和迁移能力，其主要作用方式是通过旁分泌，外泌体是主要的分泌形式。干细胞衍生的外泌体含有多种生长因子和细胞因子，可能具有促进皮肤修复和延缓皮肤衰老的巨大潜力。方法:本文综述了紫外线诱导皮肤光老化的机制、干细胞外泌体抗皮肤光老化的研究进展、外泌体治疗的新兴应用途径和应用局限性。结果:来自各种干细胞的外泌体具有防止皮肤光老化的潜力。结论:与新型材料的结合可能是其实际应用的关键一步，可能是未来基础研究和实际应用的重要方向。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Photodermatology, photoimmunology & photomedicine 医学-皮肤病学

CiteScore

4.40

自引率

7.70%

发文量

审稿时长

6-12 weeks

期刊介绍： The journal is a forum for new information about the direct and distant effects of electromagnetic radiation (ultraviolet, visible and infrared) mediated through skin. The divisions of the editorial board reflect areas of specific interest: aging, carcinogenesis, immunology, instrumentation and optics, lasers, photodynamic therapy, photosensitivity, pigmentation and therapy. Photodermatology, Photoimmunology & Photomedicine includes original articles, reviews, communications and editorials. Original articles may include the investigation of experimental or pathological processes in humans or animals in vivo or the investigation of radiation effects in cells or tissues in vitro. Methodology need have no limitation; rather, it should be appropriate to the question addressed.