Extracellular vesicles: Emerging mediators of cell communication in gastrointestinal cancers exhibiting metabolic abnormalities

IF 9.3 2区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cytokine & Growth Factor Reviews Pub Date : 2023-10-01 DOI:10.1016/j.cytogfr.2023.08.001

Ghazaleh Pourali , Nima Zafari , Hamid Fiuji , Jyotsna Batra , Elham Nazari , Majid Khazaei , Seyed Mahdi Hassanian , Mahrou Vahabi , MohammadAli Kiani , Majid Ghayour-Mobarhan , Godefridus J. Peters , Gordon A. Ferns , Alfred King-yin Lam , Elisa Giovannetti , Amir Avan

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引用次数: 0

Abstract

There is a complex interaction between pro-tumoural and anti-tumoural networks in the tumour microenvironment (TME). Throughout tumourigenesis, communication between malignant cells and various cells of the TME contributes to metabolic reprogramming. Tumour Dysregulation of metabolic pathways offer an evolutional advantage in the TME and enhance the tumour progression, invasiveness, and metastasis. Therefore, understanding these interactions within the TME is crucial for the development of innovative cancer treatments. Extracellular vesicles (EVs) serve as carriers of various materials that include microRNAs, proteins, and lipids that play a vital role in the communication between tumour cells and non-tumour cells. EVs are actively involved in the metabolic reprogramming process. This review summarized recent findings regarding the involvement of EVs in the metabolic reprogramming of various cells in the TME of gastrointestinal cancers. Additionally, we highlight identified microRNAs involved in the reprogramming process in this group of cancers and explained the abnormal tumour metabolism targeted by exosomal cargos as well as the novel potential therapeutic approaches.

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细胞外小泡：表现出代谢异常的胃肠道癌症中新出现的细胞通讯介质。

在肿瘤微环境（TME）中，促肿瘤和抗肿瘤网络之间存在复杂的相互作用。在整个肿瘤发生过程中，恶性细胞和TME的各种细胞之间的通讯有助于代谢重编程。肿瘤代谢途径的失调在TME中提供了进化优势，并增强了肿瘤的进展、侵袭性和转移。因此，了解TME中的这些相互作用对于开发创新的癌症治疗至关重要。细胞外小泡（EV）是各种材料的载体，包括在肿瘤细胞和非肿瘤细胞之间的通讯中发挥重要作用的微小RNA、蛋白质和脂质。EVs积极参与代谢重编程过程。这篇综述总结了EVs参与胃肠道癌症TME中各种细胞代谢重编程的最新发现。此外，我们强调了在这组癌症中参与重编程过程的已鉴定的微小RNA，并解释了外泌体货物靶向的异常肿瘤代谢以及新的潜在治疗方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cytokine & Growth Factor Reviews 生物-生化与分子生物学

CiteScore

21.10

自引率

1.50%

发文量

审稿时长

22 days

期刊介绍： Cytokine & Growth Factor Reviews is a leading publication that focuses on the dynamic fields of growth factor and cytokine research. Our journal offers a platform for authors to disseminate thought-provoking articles such as critical reviews, state-of-the-art reviews, letters to the editor, and meeting reviews. We aim to cover important breakthroughs in these rapidly evolving areas, providing valuable insights into the multidisciplinary significance of cytokines and growth factors. Our journal spans various domains including signal transduction, cell growth and differentiation, embryonic development, immunology, tumorigenesis, and clinical medicine. By publishing cutting-edge research and analysis, we aim to influence the way researchers and experts perceive and understand growth factors and cytokines. We encourage novel expressions of ideas and innovative approaches to organizing content, fostering a stimulating environment for knowledge exchange and scientific advancement.