Cardiorespiratory fitness components in relation to clinical characteristics, disease state and medication intake: A patient registry study

IF 1.3 4区医学 Q4 PHYSIOLOGY

Clinical Physiology and Functional Imaging Pub Date : 2023-06-14 DOI:10.1111/cpf.12842

Nicholas Cauwenberghs, Josephine Sente, František Sabovčik, Evangelos Ntalianis, Kristofer Hedman, Jomme Claes, Kaatje Goetschalckx, Véronique Cornelissen, Tatiana Kuznetsova

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引用次数: 1

Abstract

Background

Interpretation of cardiopulmonary exercise testing (CPET) results requires thorough understanding of test confounders such as anthropometrics, comorbidities and medication. Here, we comprehensively assessed the clinical determinants of cardiorespiratory fitness and its components in a heterogeneous patient sample.

Methods

We retrospectively collected medical and CPET data from 2320 patients (48.2% females) referred for cycle ergometry at the University Hospital Leuven, Belgium. We assessed clinical determinants of peak CPET indexes of cardiorespiratory fitness (CRF) and its hemodynamic and ventilatory components using stepwise regression and quantified multivariable-adjusted differences in indexes between cases and references.

Results

Lower peak load and peak O₂ uptake were related to: higher age, female sex, lower body height and weight, and higher heart rate; to the intake of beta blockers, analgesics, thyroid hormone replacement and benzodiazepines; and to diabetes mellitus, chronic kidney disease, non-ST elevation myocardial infarction and atrial fibrillation (p < 0.05 for all). Lower peak load also correlated with obstructive pulmonary diseases. Stepwise regression revealed associations of hemodynamic and ventilatory indexes (including heart rate, O₂ pulse, systolic blood pressure and ventilation at peak exercise and ventilatory efficiency) with age, sex, body composition and aforementioned diseases and medications. Multivariable-adjusted differences in CPET metrics between cases and controls confirmed the associations observed.

Conclusion

We described known and novel associations of CRF components with demographics, anthropometrics, cardiometabolic and pulmonary diseases and medication intake in a large patient sample. The clinical implications of long-term noncardiovascular drug intake for CPET results require further investigation.

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与临床特征、疾病状态和药物摄入相关的心肺健康成分:一项患者登记研究

背景:对心肺运动试验(CPET)结果的解释需要彻底了解测试混杂因素，如人体测量学、合并症和药物。在这里，我们全面评估了一个异质患者样本中心肺健康的临床决定因素及其组成部分。方法回顾性收集2320例在比利时鲁汶大学医院接受周期几何测量的患者(48.2%为女性)的医学和CPET数据。我们使用逐步回归和量化病例与文献之间经多变量调整的指标差异来评估心肺功能(CRF)的峰值CPET指数及其血流动力学和通气成分的临床决定因素。结果较低的峰值负荷和较低的峰值摄氧量与以下因素有关:年龄越大、性别越大、身高和体重越低、心率越高;对受体阻滞剂、镇痛药、甲状腺激素替代品和苯二氮卓类药物的摄入;糖尿病、慢性肾病、非st段抬高型心肌梗死和房颤(p < 0.05)。低峰值负荷也与阻塞性肺疾病相关。逐步回归显示血液动力学和通气指标(包括心率、氧脉冲、收缩压、运动高峰通气和通气效率)与年龄、性别、身体成分、上述疾病和药物有关。病例和对照组之间CPET指标的多变量调整差异证实了观察到的关联。结论:我们在大量患者样本中描述了已知的和新的CRF成分与人口统计学、人体测量学、心脏代谢和肺部疾病以及药物摄入的关联。长期服用非心血管类药物对CPET结果的临床意义有待进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Physiology and Functional Imaging 医学-生理学

CiteScore

3.40

自引率

5.60%

发文量

审稿时长

6-12 weeks

期刊介绍： Clinical Physiology and Functional Imaging publishes reports on clinical and experimental research pertinent to human physiology in health and disease. The scope of the Journal is very broad, covering all aspects of the regulatory system in the cardiovascular, renal and pulmonary systems with special emphasis on methodological aspects. The focus for the journal is, however, work that has potential clinical relevance. The Journal also features review articles on recent front-line research within these fields of interest. Covered by the major abstracting services including Current Contents and Science Citation Index, Clinical Physiology and Functional Imaging plays an important role in providing effective and productive communication among clinical physiologists world-wide.