Associations of Telomere Length and Change With Cognitive Decline Were Modified by Sex and Race: The REGARDS Study.

IF 2.7 4区医学 Q2 CLINICAL NEUROLOGY

American Journal of Alzheimers Disease and Other Dementias Pub Date : 2023-01-01 DOI:10.1177/15333175231175797

Cheng Chen, Keming Yang, Hongmei Nan, Frederick Unverzagt, Leslie A McClure, Marguerite R Irvin, Suzanne Judd, Mary Cushman, Debora Kamin Mukaz, James E Klaunig, Mary E D'Alton, Ka Kahe

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引用次数: 0

Abstract

Introduction: We examined the associations of baseline telomere length (TL) and TL change with cognitive function over time in older US adults, as well as differences by sex and race.

Methods: A total of 1820 cognitively healthy individuals (median baseline age: 63 years) were included. Telomere length was measured using qPCR-based method at baseline and among 614 participants in the follow-up examination 10 years later. Cognitive function was assessed by a four-test battery every 2 years.

Results: In multivariable-adjusted linear mixed models, longer baseline TL and smaller attrition/lengthening of TL over time were associated with better Animal Fluency Test score. Longer baseline TL was also linearly associated with better Letter Fluency Test score. The observed associations were consistently more pronounced in women than men and in Black compared to White participants.

Discussion: Telomere length may be a biomarker that predicts long-term verbal fluency and executive function, particularly in women and Black Americans.

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端粒长度和变化与认知能力下降的关系因性别和种族而改变：REGARDS研究。

引言：我们研究了美国老年人基线端粒长度（TL）和TL随时间变化与认知功能的关系，以及性别和种族的差异。方法：共纳入1820名认知健康个体（中位基线年龄：63岁）。在基线和10年后的随访检查中，614名参与者使用基于qPCR的方法测量了端粒长度。每2年通过四组测试来评估认知功能。结果：在多变量调整的线性混合模型中，随着时间的推移，较长的基线TL和较小的TL磨损/延长与更好的动物流利性测试分数相关。较长的基线TL也与较好的字母流利性测试分数线性相关。观察到的关联在女性参与者中始终比男性更明显，在黑人参与者中也比白人参与者更明显。讨论：端粒长度可能是预测长期语言流利性和执行功能的生物标志物，尤其是在女性和美国黑人中。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American Journal of Alzheimers Disease and Other Dementias GERIATRICS & GERONTOLOGY-CLINICAL NEUROLOGY

CiteScore

5.40

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： American Journal of Alzheimer''s Disease and other Dementias® (AJADD) is for professionals on the frontlines of Alzheimer''s care, dementia, and clinical depression--especially physicians, nurses, psychiatrists, administrators, and other healthcare specialists who manage patients with dementias and their families. This journal is a member of the Committee on Publication Ethics (COPE).