The ATP-sensitive potassium channel: a therapeutic target for neurodegeneration?

Abstract

In 1983, NOMA first discovered ATP sensitive potassium channels (KATP channels) through patch clamp technology, which are widely distributed in the brain and can couple cell energy states and electrical activities. KATP channels remain in a closed state under normal physiological conditions, however, KATP channels are selectively activated in pathological state [1]. Although a large number of literatures has reported that KATP channels are involved in the occurrence and development of neurodegenerative diseases, the mechanism of its role has not yet been clarified [2]. It is of great significance to further explore the important role of KATP channels and the related drugs in neurodegenerative diseases.