Systematic reviews and meta-analyses on androgen administration in humans: an umbrella review.

IF 2.6 3区医学 Q3 ENDOCRINOLOGY & METABOLISM

Current Opinion in Endocrinology & Diabetes and Obesity Pub Date : 2023-12-01 Epub Date: 2023-08-21 DOI:10.1097/MED.0000000000000832

Razieh Chegeni, Ståle Pallesen, Hailemariam Weldemariam, Dominic Sagoe

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Abstract

Purpose of review: The present umbrella review systematically searches and synthesizes recent (2021-2023) systematic reviews and meta-analyses (SRMA) on androgen administration in humans.

Recent findings: Results from 19 SRMA are synthesized. Four themes were identified: market for androgens, prevalence of androgen abuse, psychological effects of androgens, and clinical/therapeutic effects of androgens. One of three androgens on the illicit market are fake or substandard. Whereas one of three androgen users experiences dependence and various serious disorders, only one of three androgen users seeks physician support. Additionally, androgen administration increases self-reported aggression in healthy male individuals, and abuse positively correlates with interpersonal violence. Furthermore, androgen therapy is beneficial in treating persons suffering from various chronic diseases.

Summary: In this umbrella review, we identified 19 SRMA on androgen use and abuse. Results show a high prevalence of fake androgens on the illicit market, a high prevalence of androgen abuse and dependence, and that a huge proportion of androgen users tend to avoid seeking support from clinicians. Also, androgen administration increases self-reported aggression among healthy male, and there is a positive correlation between androgen abuse and violent behavior. Finally, androgens have multiple therapeutic effects on various pathology.

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人类雄激素给药的系统综述和荟萃分析：一项总括性综述。

综述目的：本综述系统地检索和综合了最近（2021-2023）关于人类雄激素给药的系统综述和荟萃分析（SRMA）。最近的发现：综合了19个SRMA的结果。确定了四个主题：雄激素的市场、雄激素滥用的流行率、雄激素的心理影响和雄激素的临床/治疗效果。非法市场上的三种雄激素中有一种是假的或不合格的。三分之一的雄激素使用者有依赖性和各种严重疾病，而三分之一雄激素使用者寻求医生支持。此外，雄激素给药会增加健康男性自我报告的攻击性，虐待与人际暴力呈正相关。此外，雄激素治疗对治疗患有各种慢性疾病的人是有益的。总结：在这篇总括性综述中，我们确定了19例关于雄激素使用和滥用的SRMA。结果显示，非法市场上假雄激素的流行率很高，雄激素滥用和依赖的流行率也很高，而且很大一部分雄激素使用者倾向于避免寻求临床医生的支持。此外，雄激素给药增加了健康男性自我报告的攻击性，雄激素滥用与暴力行为之间存在正相关。最后，雄激素对各种病理有多种治疗作用。

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来源期刊

Current Opinion in Endocrinology & Diabetes and Obesity ENDOCRINOLOGY & METABOLISM-

CiteScore

5.80

自引率

3.10%

发文量

128

审稿时长

6-12 weeks

期刊介绍： Current Opinion in Endocrinology, Diabetes and Obesity delivers a broad-based perspective on the most recent and exciting developments in the field from across the world. Published bimonthly and featuring twelve key topics – including androgens, gastrointestinal hormones, diabetes and the endocrine pancreas, and neuroendocrinology – the journal’s renowned team of guest editors ensure a balanced, expert assessment of the recently published literature in each respective field with insightful editorials and on-the-mark invited reviews.