HbA1c/C-peptide ratio is associated with angiographic thrombus burden and short-term mortality in patients presenting with ST-elevation myocardial infarction.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-09-01 DOI:10.1097/MBC.0000000000001240

Kenan Toprak, Mustafa Kaplangöray, Tolga Memioğlu, Mehmet İnanir, Bahadir Omar, Mustafa Beğenç Taşcanov, Asuman Biçer, Recep Demirbağ

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引用次数: 0

Abstract

Objectives: Angiographic high thrombus burden (HTB) is associated with increased adverse cardiovascular events in patients with ST-elevation myocardial infarction (STEMI). HbA1c and C-peptide are two interrelated bioactive markers that affect many cardiovascular pathways. HbA1c exhibits prothrombogenic properties, while C-peptide, in contrast, exhibits antithrombogenic effects. In this study, we aimed to demonstrate the value of combining these two biomarkers in a single fraction in predicting HTB and short-term mortality in patients with STEMI.

Methods: 1202 patients who underwent primary percutaneous coronary intervention (pPCI) for STEMI were retrospectively included in this study. The study population was divided into thrombus burden (TB) groups and compared in terms of basic clinical demographics, laboratory parameters and HbA1c/C-peptide ratios (HCR). In addition, short-term mortality of the study population was compared according to HCR and TB categories.

Results: HCR values were significantly higher in the HTB group than in the LTB group (3.5 ± 1.2 vs. 2.0 ± 1.1; P < 0.001; respectively). In the multivariable regression analysis, HCR was determined as an independent predictor of HTB both as a continuous variable [odds ratio (OR): 2.377; confidence interval (CI): 2.090-2.704; P < 0.001] and as a categorical variable (OR: 5.492; CI: 4.115-7.331; P < 0.001). In the receiver operating characteristic (ROC) analysis, HCR predicted HTB with 73% sensitivity and 72% specificity, and furthermore, HCR's predictive value for HTB was superior to HbA1c and C-peptide. The Kaplan-Meier cumulative survival curve showed that short-term mortality increased at HTB. In addition, HCR strongly predicted short-term mortality in Cox regression analysis.

Conclusions: In conclusion, HCR is closely associated with HTB and short-term mortality in STEMI patients.

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st段抬高型心肌梗死患者的HbA1c/ c肽比值与血管造影血栓负担和短期死亡率相关。

目的:血管造影高血栓负担(HTB)与st段抬高型心肌梗死(STEMI)患者不良心血管事件增加相关。HbA1c和c肽是两个相互关联的生物活性标志物，影响许多心血管途径。HbA1c表现出血栓形成前的特性，而c肽则相反，表现出抗血栓形成的作用。在这项研究中，我们旨在证明将这两种生物标志物结合在一个分数中预测STEMI患者HTB和短期死亡率的价值。方法:回顾性分析1202例经皮冠状动脉介入治疗STEMI的患者。将研究人群分为血栓负担(TB)组，比较基本临床人口学、实验室参数和HbA1c/ c -肽比值(HCR)。此外，根据HCR和结核病分类比较了研究人群的短期死亡率。结果:HTB组HCR值显著高于LTB组(3.5±1.2 vs 2.0±1.1;P结论:总之，HCR与STEMI患者HTB和短期死亡率密切相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.