Elevated serum uric acid is a risk factor for progression to prediabetes in Japanese women: A 5-year retrospective chort study

IF 3.2 3区医学

Journal of Diabetes Investigation Pub Date : 2023-08-08 DOI:10.1111/jdi.14064

Masanori Shimodaira, Yu Minemura, Tomohiro Nakayama

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引用次数: 1

Abstract

Aims/Introduction

The association between serum uric acid (SUA) levels and prediabetes risk remains poorly understood. The aim of this longitudinal retrospective study was to evaluate the association between SUA levels and prediabetes progression in Japanese individuals through sex-specific analysis.

Materials and Methods

We enrolled 20,743 participants (11,916 men and 8,827 women) who underwent annual medical health checkups in 2017 (baseline) and 2022. None of the participants had diabetes and prediabetes or were taking SUA-lowering medications at baseline. Participants were divided into four groups according to the quartiles of SUA levels at baseline. Multivariable-adjusted Cox regression analysis was conducted to examine the risk of prediabetes progression. In addition, multivariate restricted cubic spline analysis was conducted to investigate the dose–response risk.

Results

In women, compared with the lowest SUA quartile (Q1) group, the adjusted hazard ratios (95% confidence intervals) of prediabetes in the Q2, Q3, and Q4 groups were 1.03 (0.86–1.25), 1.41 (1.18–1.68), and 1.55 (1.30–1.84), respectively. However, in men, no significant association in the risk of prediabetes was found across quartiles of SUA. Furthermore, in women, restricted cubic spline analysis revealed the dose–response relationship between SUA and progression to prediabetes.

Conclusions

The results indicate that elevated serum SUA levels might be positively and independently associated with an increased risk of progression to prediabetes in Japanese women.

Abstract Image

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血清尿酸升高是日本女性发展为糖尿病前期的危险因素：一项5年回顾性chort研究。

目的/简介：血清尿酸（SUA）水平与糖尿病前期风险之间的关系尚不清楚。这项纵向回顾性研究的目的是通过性别特异性分析来评估日本个体SUA水平与糖尿病前期进展之间的关系。材料和方法：我们招募了20743名参与者（11916名男性和8827名女性），他们在2017年（基线）和2022年接受了年度医疗健康检查。没有一名参与者患有糖尿病和糖尿病前期，也没有在基线时服用降低SUA的药物。根据基线时SUA水平的四分位数，参与者被分为四组。进行多变量校正Cox回归分析，以检查糖尿病前期进展的风险。此外，还进行了多变量限制性三次样条分析，以研究剂量反应风险。结果：在女性中，与SUA最低四分位数（Q1）组相比，Q2、Q3和Q4组糖尿病前期的调整后风险比（95%置信区间）分别为1.03（0.86-1.25）、1.41（1.18-1.68）和1.55（1.30-1.84）。然而，在男性中，在SUA的四分位数中没有发现糖尿病前期风险的显著相关性。此外，在女性中，限制性三次样条分析揭示了SUA与糖尿病前期进展之间的剂量-反应关系。结论：研究结果表明，血清SUA水平升高可能与日本女性发展为糖尿病前期的风险增加呈正相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Diabetes Investigation Medicine-Internal Medicine

自引率

9.40%

发文量

218

期刊介绍： Journal of Diabetes Investigation is your core diabetes journal from Asia; the official journal of the Asian Association for the Study of Diabetes (AASD). The journal publishes original research, country reports, commentaries, reviews, mini-reviews, case reports, letters, as well as editorials and news. Embracing clinical and experimental research in diabetes and related areas, the Journal of Diabetes Investigation includes aspects of prevention, treatment, as well as molecular aspects and pathophysiology. Translational research focused on the exchange of ideas between clinicians and researchers is also welcome. Journal of Diabetes Investigation is indexed by Science Citation Index Expanded (SCIE).