Skeletal Muscle Nrf2 Contributes to Exercise-Evoked Systemic Antioxidant Defense Via Extracellular Vesicular Communication.

IF 4.9 2区医学 Q1 PHYSIOLOGY

Exercise and Sport Sciences Reviews Pub Date : 2021-07-01 DOI:10.1249/JES.0000000000000257

Lie Gao, Han-Jun Wang, Changhai Tian, Irving H Zucker

引用次数: 15

Abstract

This review explores the hypothesis that the repetitive contraction-relaxation that occurs during chronic exercise activates skeletal myocyte nuclear factor erythroid-derived 2-like 2 (Nrf2) to upregulate antioxidant enzymes. These proteins are secreted into the circulation within extracellular vesicles and taken up by remote cells, thus providing remote organs with cytoprotection against subsequent oxidative stress.

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骨骼肌Nrf2通过细胞外水泡通讯参与运动诱发的系统性抗氧化防御。

这篇综述探讨了慢性运动中发生的重复收缩-放松的假设，激活骨骼肌细胞核因子红源性2-样2 (Nrf2)上调抗氧化酶。这些蛋白质被分泌到细胞外囊泡的循环中，并被远处的细胞吸收，从而为远处的器官提供细胞保护，防止随后的氧化应激。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Exercise and Sport Sciences Reviews 社会科学-生理学

CiteScore

10.70

自引率

1.80%

发文量

期刊介绍： Exercise and Sport Sciences Reviews made the transition from an annual hardcover series book to a quarterly journal in January 2000. The mission of this American College of Sports Medicine publication is to provide premier quarterly reviews of the most contemporary scientific, medical, and research-based topics emerging in the field of sports medicine and exercise science. The publication strives to provide the most relevant, topical information to students, professors, clinicians, scientists, and professionals for practical and research applications.