Early or late response in poor responders: does it make a difference in cycle outcome?

IF 2.1 4区医学 Q2 OBSTETRICS & GYNECOLOGY

Human Fertility Pub Date : 2023-12-01 Epub Date: 2023-06-16 DOI:10.1080/14647273.2023.2197627

Inci Kahyaoglu, Elif Ceren Tutkun Kilinc, Cavidan Gulerman, Nafiye Yilmaz, Mehmet Ufuk Ceran, Yesim Bardakci, Yaprak Engin Ustun

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引用次数: 0

Abstract

Ovarian response to stimulation mainly determines the length of stimulation. However, there is no clarity in the literature regarding the optimal duration required to achieve oocyte maturity in patients with the poor ovarian response (POR) defined by Bologna criteria. Therefore, a total of 267 cycles that fulfilled the inclusion criteria were selected retrospectively. Group A constitute of patients with a stimulation period < 9 d (n = 70); and group B included patients with a stimulation period ≥ 9 d (n = 133). The results showed that antral follicle count (5.72 ± 1.82 vs. 5.10 ± 1.78, p = 0.023), serum oestradiol level on hCG day (1286.88 ± 778.18 pg/mL vs. 820.14 ± 479.04 pg/mL, p = 0.001), and total gonadotropin dose used (2949.53 ± 727.92 IU vs 2020.94 ± 415.17 IU, p = 0.0001) were higher in group B when compared to group A. Although the number of total (5.47 ± 3.32 vs 3.86 ± 2.15, p = 0.0001) and mature oocytes retrieved (4.34 ± 2.88 vs 2.84 ± 1.67, p = 0.0001) were higher in group B, no significant difference was observed in the pregnancy rates between groups (25.6 vs 15.7%, p > 0.05). In conclusion, no deleterious effect of a shorter duration of stimulation on cycle outcome was seen in patients with POR.

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对不良反应者的早期或晚期反应：对周期结果有影响吗？

卵巢对刺激的反应主要决定了刺激时间的长短。然而，对于博洛尼亚标准中定义的卵巢反应差（POR）患者而言，达到卵母细胞成熟所需的最佳时间，文献中并没有明确的规定。因此，我们回顾性地选择了符合纳入标准的 267 个周期。A组包括刺激期<9 d的患者（70人）；B组包括刺激期≥9 d的患者（133人）。结果显示，A 组患者前卵泡数（5.72 ± 1.82 vs. 5.10 ± 1.78，P = 0.023）、hCG 日血清雌二醇水平（1286.88 ± 778.18 pg/mL vs. 820.14 ± 479.04 pg/mL，P = 0.001）、促性腺激素总剂量（2949.53 ± 727.92 IU vs 2020.94 ± 415.17 IU，P = 0.虽然 B 组获得的总卵母细胞数（5.47 ± 3.32 vs 3.86 ± 2.15，p = 0.0001）和成熟卵母细胞数（4.34 ± 2.88 vs 2.84 ± 1.67，p = 0.0001）高于 A 组，但两组间的妊娠率无显著差异（25.6 vs 15.7%，p > 0.05）。总之，在 POR 患者中，较短的刺激时间不会对周期结果产生有害影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Human Fertility OBSTETRICS & GYNECOLOGY-REPRODUCTIVE BIOLOGY

CiteScore

3.30

自引率

5.30%

发文量

期刊介绍： Human Fertility is a leading international, multidisciplinary journal dedicated to furthering research and promoting good practice in the areas of human fertility and infertility. Topics included span the range from molecular medicine to healthcare delivery, and contributions are welcomed from professionals and academics from the spectrum of disciplines concerned with human fertility. It is published on behalf of the British Fertility Society. The journal also provides a forum for the publication of peer-reviewed articles arising out of the activities of the Association of Biomedical Andrologists, the Association of Clinical Embryologists, the Association of Irish Clinical Embryologists, the British Andrology Society, the British Infertility Counselling Association, the Irish Fertility Society and the Royal College of Nursing Fertility Nurses Group. All submissions are welcome. Articles considered include original papers, reviews, policy statements, commentaries, debates, correspondence, and reports of sessions at meetings. The journal also publishes refereed abstracts from the meetings of the constituent organizations.