A quick test to objectify smell and taste dysfunction at home: a proof of concept for the validation of the chemosensory perception test.

IF 2.8 4区 心理学 Q1 BEHAVIORAL SCIENCES
Cindy Levesque-Boissonneault, Nicholas Bussière, Frédérique Roy-Côté, Frank Cloutier, Marie-Ève Caty, Johannes Frasnelli
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引用次数: 0

Abstract

Recent studies have shown the efficacy of a home test for the self-evaluation of olfactory and gustatory functions in quarantined coronavirus disease-2019 (COVID-19) patients. However, testing was often limited to COVID-19 participants, and the accuracy of home test kits was rarely compared to standardized testing. This study aims at providing proof of concept for the validation of the new Chemosensory Perception Test (CPT) developed to remotely assess orthonasal olfactory, retronasal olfactory, and gustatory functions in various populations using common North American household items. In the 2 experiments, a total of 121 participants irrespective of having olfactory and/or gustatory complaints from various causes (COVID-19, sinunasal, post-viral, idiopathic) were tested first, with one or many of the following tests: (i) a brief chemosensory questionnaire, (ii) an olfactory test-Sniffin' Sticks Test (SST) or University of Pennsylvania Smell Identification Test (UPSIT), and/or (iii) a gustatory test-Brief Waterless Empirical Taste Test (B-WETT). We then applied the CPT which yielded 3 different subscores, namely orthonasal, retronasal, and gustatory CPT scores. The orthonasal CPT score was significantly correlated with SST (ρ = 0.837, P < 0.001) and UPSIT (ρ = 0.364, P < 0.001) scores, and exhibited an excellent accuracy to identify olfactory dysfunction (OD) as compared to SST (area under the curve [AUC]: 0.923 [95% confidence interval {CI}, 0.822-1.000], P < 0.001). The retronasal CPT score but not the gustatory CPT score allowed to distinguish between participants with or without subjective gustatory complaint (AUC: 0.818 [95% CI, 0.726-0.909], P < 0.001). The CPT has the ability to identify OD and to quantify subjective gustatory complaints.

在家进行嗅觉和味觉功能障碍客观化快速测试:验证化学感知测试的概念证明。
最近的研究表明,对被隔离的冠状病毒病-2019(COVID-19)患者进行嗅觉和味觉功能自我评估的家庭测试是有效的。然而,测试通常仅限于 COVID-19 参与者,而且家庭测试套件的准确性很少与标准化测试进行比较。本研究旨在为验证新开发的化感知觉测试(CPT)提供概念证明,该测试使用常见的北美家居用品远程评估不同人群的正鼻嗅觉、反鼻嗅觉和味觉功能。在这两项实验中,共有 121 名参与者,无论其嗅觉和/或味觉不适的原因是什么(COVID-19、鼻窦炎、病毒感染后、特发性),都首先接受了以下一项或多项测试:(i)简短化感问卷,(ii)嗅觉测试--嗅棒测试(SST)或宾夕法尼亚大学气味鉴别测试(UPSIT),和/或(iii)味觉测试--简短无水经验味觉测试(B-WETT)。然后,我们进行了 CPT 测试,并得出了 3 个不同的子分数,即正鼻腔、反鼻腔和味觉 CPT 分数。正鼻腔 CPT 分数与 SST 分数(ρ = 0.837,P < 0.001)和 UPSIT 分数(ρ = 0.364,P < 0.001)显著相关,与 SST 相比,正鼻腔 CPT 在识别嗅觉功能障碍(OD)方面表现出极高的准确性(曲线下面积 [AUC]:0.923 [95% 置信度]):0.923[95%置信区间{CI},0.822-1.000],P <0.001)。再鼻腔 CPT 评分而非味觉 CPT 评分可区分有无主观味觉不适的参与者(AUC:0.818 [95% CI,0.726-0.909],P <0.001)。CPT 具有识别 OD 和量化主观味觉主诉的能力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Chemical Senses
Chemical Senses 医学-行为科学
CiteScore
8.60
自引率
2.90%
发文量
25
审稿时长
1 months
期刊介绍: Chemical Senses publishes original research and review papers on all aspects of chemoreception in both humans and animals. An important part of the journal''s coverage is devoted to techniques and the development and application of new methods for investigating chemoreception and chemosensory structures.
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