Metabolic imaging with deuterium labeled substrates

IF 7.3 2区化学 Q2 CHEMISTRY, PHYSICAL

Progress in Nuclear Magnetic Resonance Spectroscopy Pub Date : 2023-04-01 DOI:10.1016/j.pnmrs.2023.02.002

Jacob Chen Ming Low, Alan J. Wright, Friederike Hesse, Jianbo Cao, Kevin M. Brindle

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引用次数: 5

Abstract

Deuterium metabolic imaging (DMI) is an emerging clinically-applicable technique for the non-invasive investigation of tissue metabolism. The generally short T₁ values of ²H-labeled metabolites in vivo can compensate for the relatively low sensitivity of detection by allowing rapid signal acquisition in the absence of significant signal saturation. Studies with deuterated substrates, including [6,6′-²H₂]glucose, [²H₃]acetate, [²H₉]choline and [2,3-²H₂]fumarate have demonstrated the considerable potential of DMI for imaging tissue metabolism and cell death in vivo. The technique is evaluated here in comparison with established metabolic imaging techniques, including PET measurements of 2-deoxy-2-[¹⁸F]fluoro-d-glucose (FDG) uptake and ¹³C MR imaging of the metabolism of hyperpolarized ¹³C-labeled substrates.

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氘标记底物的代谢成像

氘代谢成像（DMI）是一种新兴的临床应用技术，用于非侵入性研究组织代谢。体内2H标记代谢物的通常较短的T1值可以通过在没有显著信号饱和的情况下允许快速信号采集来补偿相对较低的检测灵敏度。对氘化底物，包括[6,6′-2H2]葡萄糖、[2H3]乙酸盐、[2H9]胆碱和[2,3-2H2]富马酸盐的研究表明，DMI在体内组织代谢和细胞死亡成像方面具有相当大的潜力。该技术在此与已建立的代谢成像技术进行比较，包括2-脱氧-2-[18F]氟-d-葡萄糖（FDG）摄取的PET测量和超极化13C-标记底物代谢的13C-MR成像。

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来源期刊

Progress in Nuclear Magnetic Resonance Spectroscopy 物理-光谱学

CiteScore

14.30

自引率

8.20%

发文量

审稿时长

62 days

期刊介绍： Progress in Nuclear Magnetic Resonance Spectroscopy publishes review papers describing research related to the theory and application of NMR spectroscopy. This technique is widely applied in chemistry, physics, biochemistry and materials science, and also in many areas of biology and medicine. The journal publishes review articles covering applications in all of these and in related subjects, as well as in-depth treatments of the fundamental theory of and instrumental developments in NMR spectroscopy.