Post-transcriptional regulation of erythropoiesis.

IF 1.5 Q3 HEMATOLOGY
Yanan Li, Haihang Zhang, Bin Hu, Pan Wang, Wei Wang, Jing Liu
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Abstract

Erythropoiesis is a complex, precise, and lifelong process that is essential for maintaining normal body functions. Its strict regulation is necessary to prevent a variety of blood diseases. Normal erythropoiesis is precisely regulated by an intricate network that involves transcription levels, signal transduction, and various epigenetic modifications. In recent years, research on post-transcriptional levels in erythropoiesis has expanded significantly. The dynamic regulation of splicing transitions is responsible for changes in protein isoform expression that add new functions beneficial for erythropoiesis. RNA-binding proteins adapt the translation of transcripts to the protein requirements of the cell, yielding mRNA with dynamic translation efficiency. Noncoding RNAs, such as microRNAs and lncRNAs, are indispensable for changing the translational efficiency and/or stability of targeted mRNAs to maintain the normal expression of genes related to erythropoiesis. N6-methyladenosine-dependent regulation of mRNA translation plays an important role in maintaining the expression programs of erythroid-related genes and promoting erythroid lineage determination. This review aims to describe our current understanding of the role of post-transcriptional regulation in erythropoiesis and erythroid-associated diseases, and to shed light on the physiological and pathological implications of the post-transcriptional regulation machinery in erythropoiesis. These may help to further enrich our understanding of the regulatory network of erythropoiesis and provide new strategies for the diagnosis and treatment of erythroid-related diseases.

Abstract Image

Abstract Image

Abstract Image

红细胞生成的转录后调控。
红细胞生成是一个复杂的、精确的、终生的过程,对维持正常的身体功能至关重要。它的严格规定是必要的,以防止各种血液疾病。正常的红细胞生成是由一个复杂的网络精确调节的,这个网络涉及转录水平、信号转导和各种表观遗传修饰。近年来,对红细胞生成的转录后水平的研究有了显著的扩展。剪接过渡的动态调控导致了蛋白异构体表达的变化,从而增加了有利于红细胞生成的新功能。rna结合蛋白使转录本的翻译适应细胞对蛋白质的需求,产生具有动态翻译效率的mRNA。非编码rna,如microRNAs和lncRNAs,对于改变靶mrna的翻译效率和/或稳定性以维持红细胞生成相关基因的正常表达是不可或缺的。n6 -甲基腺苷依赖的mRNA翻译调控在维持红系相关基因的表达程序和促进红系谱系确定中起着重要作用。这篇综述旨在描述我们目前对转录后调控在红细胞生成和红细胞相关疾病中的作用的理解,并阐明红细胞生成中转录后调控机制的生理和病理意义。这可能有助于进一步丰富我们对红细胞生成调控网络的认识,并为红细胞相关疾病的诊断和治疗提供新的策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
1.70
自引率
0.00%
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审稿时长
10 weeks
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