Intermittent vs. continuous swimming training on adipokines and pro-inflammatory cytokines in metabolic syndrome experimental model.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-08-17 eCollection Date: 2023-09-01 DOI:10.1515/hmbci-2022-0004

Shila Nayebifar, Hossein Nakhaei, Zohreh Borhani Kakhki, Elham Ghasemi

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引用次数: 0

Abstract

Objectives: In this study, metabolic syndrome-affected rats were studied to examine how intermittent and continuous swimming training influenced adipokines and pro-inflammatory cytokines.

Methods: Forty-eight male Wistar rats were randomized in this experimental study into four groups (n=8), including normal control (NC), metabolic syndrome (MS), continuous swimming training with metabolic syndrome (CT-MS: load 0-3% body mass, 5 d/wk, for 8 weeks), and intermittent swimming training with metabolic syndrome (IT-MS: load 5-16% body mass, 5 d/wk, for 8 weeks). The serum levels of metrnl, adipolin, irisin, leptin, TNF-α, and IL-6 were measured using the ELISA test.

Results: The IT-MS and NC groups exhibited significantly lower leptin concentrations than the CT-MS group (p=0.001). The irisin, meteorin, and adipolin serum levels increased significantly in CT-MS and IT relative to the NC and CT-MS groups (p=0.001), with the changes being more pronounced in the IT group (p=0.05). TNF-α and IL-6 were inclined in the CT-MS group compared with the other three groups (p=0.001), while IL-6 was increased in the IT group (p=0.024).

Conclusions: Intermittent swimming is more effective than continuous swimming training in improving adipokines in rats with metabolic syndrome.

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代谢综合征实验模型中脂肪因子和促炎细胞因子的间歇与连续游泳训练。

目的：在本研究中，对代谢综合征影响的大鼠进行了研究，以了解间歇性和连续游泳训练如何影响脂肪因子和促炎细胞因子。方法：48只雄性Wistar大鼠随机分为4组（n=8），包括正常对照组（NC）、代谢综合征组（MS）、伴有代谢综合征的连续游泳训练组（CT-MS：负荷0-3%体重，5 d/周，持续8周）和伴有代谢综合症的间歇游泳训练组。采用ELISA法测定血清metrnl、阿脂蛋白、鸢尾素、瘦素、TNF-α和IL-6水平。结果：IT-MS和NC组的瘦素浓度显著低于CT-MS组（p=0.001）。与NC和CT-MS相比，CT-MS和IT组的鸢尾素、陨星蛋白和脂肪蛋白血清水平显著升高（p=0.000），与其他三组相比，CT-MS组TNF-α和IL-6呈下降趋势（p=0.001），而IT组IL-6升高（p=0.024）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.