Limited Utility of Keratic Precipitate Morphology as an Indicator of Underlying Diagnosis in Ocular Inflammation.

IF 2.6 4区医学 Q2 OPHTHALMOLOGY

Ocular Immunology and Inflammation Pub Date : 2024-10-01 Epub Date: 2023-08-14 DOI:10.1080/09273948.2023.2242946

Katherine Terence, Olivia Cundy, Salomey Kellett, Andrew D Dick, Jugnoo Rahi, Ameenat Lola Solebo

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引用次数: 0

Abstract

Objectives: We aimed to establish the degree of consensus among clinicians on descriptors of KP morphology.

Methods: A web-based exercise in which respondents associated KP descriptors, as identified through a scoping review of the published literature, to images from different disorders. Inter-observer agreement was assessed using the Krippendorff kappa alpha metric.

Results: Of the 76 descriptive terms identified by the scoping review, the most used included "mutton-fat" (n = 93 articles, 36%), "fine/dust" (n = 76, 29%), "stellate" (n = 40, 15%), "large" (n = 33, 12%), and "medium" (n = 33, 12%). The survey of specialists (n = 26) identified inter-observer agreement for these descriptors to be poor ("stellate," kappa: 0.15, 95% confidence interval 0.13-0.17), limited ("medium": 0.27, 95% CI 0.25-0.29; "dust/fine": 0.36, 95% CI 0.34-0.37), or moderate ("mutton fat": 0.40, 95% CI 0.36-0.43; "large": 0.43, 95% CI 0.39-0.46).

Conclusion: The clinical utility of KP morphology as an indicator of disease classification is limited by low inter-observer agreement.

查看原文本刊更多论文

角膜沉淀形态学作为眼部炎症基础诊断指标的作用有限。

目的我们旨在确定临床医生对 KP 形态描述的共识程度：受访者将通过对已发表文献进行范围界定而确定的 KP 描述符与不同疾病的图像进行关联。使用 Krippendorff kappa alpha 指标评估观察者之间的一致性：在范围审查确定的 76 个描述性术语中，使用最多的术语包括 "羊脂"（n = 93 篇文章，36%）、"细/尘"（n = 76 篇文章，29%）、"星状"（n = 40 篇文章，15%）、"大"（n = 33 篇文章，12%）和 "中等"（n = 33 篇文章，12%）。对专家（n = 26）的调查发现，这些描述指标的观察者间一致性较差（"星状"，kappa：0.15，95% 置信区间 0.13-0.17）、有限（"中等"：0.27，95% CI 0.25-0.29；"灰尘/细小"：0.36，95% CI 0.34-0.37）或中等（"羊肉脂肪"：0.40，95% CI 0.36-0.43；"大"：0.43，95% CI 0.39-0.46）：结论：由于观察者之间的一致性较低，KP形态学作为疾病分类指标的临床实用性受到了限制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ocular Immunology and Inflammation 医学-眼科学

CiteScore

6.20

自引率

15.20%

发文量

285

审稿时长

6-12 weeks

期刊介绍： Ocular Immunology & Inflammation ranks 18 out of 59 in the Ophthalmology Category.Ocular Immunology and Inflammation is a peer-reviewed, scientific publication that welcomes the submission of original, previously unpublished manuscripts directed to ophthalmologists and vision scientists. Published bimonthly, the journal provides an international medium for basic and clinical research reports on the ocular inflammatory response and its control by the immune system. The journal publishes original research papers, case reports, reviews, letters to the editor, meeting abstracts, and invited editorials.