Chemico-biological interactions

PP2A attenuates α-amanitin-induced liver injury by promoting autophagy and inhibiting apoptosis in mouse models.

Pub Date : 2025-05-14 DOI: 10.1016/j.cbi.2025.111558 Hui Xu, Jian Sun, Yu Zhao, Yaxiong Zhou, Kuan Wang, Xiang Liu, Jieyan Yang, Peng Wu, Shengkui Wang, John P Kastelic, Weijie Qu, Limei Zhang, Xiaolong Gu

Zn²⁺ regulates mitochondrial DNA efflux to inhibit AIM2-mediated ZBP1-PANoptosome pathway and alleviate septic myocardial injury.

Pub Date : 2025-05-08 DOI: 10.1016/j.cbi.2025.111525 Jun Guo, Shanshan Meng, Jin Zhang, Ni Wang, Fengmei Guo

Copper exposure induces inflammation and PANoptosis through the TLR4/NF-κB signaling pathway, leading to testicular damage and impaired spermatogenesis in Wilson disease.

Pub Date : 2024-06-01 DOI: 10.1016/j.cbi.2024.111060 Dan Zhao, Limin Wu, Xinru Fang, Luyao Wang, Qianzhuo Liu, Pengyu Jiang, Zhihui Ji, Nian Zhang, Miaozhu Yin, Hui Han