Chemico-biological interactions

Antifibrotic potential of reserpine (alkaloid) targeting Keap1/Nrf2; oxidative stress pathway in CCl₄-induced liver fibrosis.

Pub Date : 2025-02-01 DOI: 10.1016/j.cbi.2025.111384 Aamir Sohail, Faiza Shams, Aleeza Nawaz, Qurrat Ul Ain, Bushra Ijaz

Prophylaxis by a reversible cholinesterase inhibitor and the NMDA receptor antagonist treatment as combinatorial countermeasure against nerve agent poisoning in mice model.

Pub Date : 2025-02-01 DOI: 10.1016/j.cbi.2025.111386 Jiri Kassa, Jan Konecny, Barbora Svobodova, Martin Horak, Jan Korabecny, Ondrej Soukup

Integrated network pharmacology, bioinformatics, and experiment analysis to decipher the molecular mechanism of Salidroside on Gastric cancer via targeting NCOA4-mediated ferritinophagy.

Pub Date : 2025-02-01 DOI: 10.1016/j.cbi.2024.111368 Yu Fu, Guiqin Huang, Yawen Cai, Menghui Ren, Run Cheng, Yuhui Chai, Yingdi Wang, Yunqi An, Tianhua Yan, Lingpeng Zhu, Xinxin Liu