Chemico-biological interactions

Discovery of a new function of human butyrylcholinesterase and the catalytic activity of its natural variants toward homocysteine thiolactone hydrolysis.

Pub Date : 2025-10-22 DOI: 10.1016/j.cbi.2025.111683 Xiabin Chen, Xiaoxuan Li, Huan Liu, Jianzhuang Yao, Yishuang Li, Hualing Li, Zelin Wu, Yun Zhang, Tingjun Hou, Jiye Wang, Shurong Hou

Cigarette smoke-induced glycerophospholipid DLPC promotes macrophage ferroptosis through the USP7/GPX4 regulatory axis in chronic obstructive pulmonary disease.

Pub Date : 2025-10-22 DOI: 10.1016/j.cbi.2025.111697 Weibin Ruan, Zhimin Peng, Mingsi Huang, Hui Zhang, Xiaohua Li, Tingting Ma, Jiehua Deng, Mianluan Pan, Ziqing Mai, Xia Meng, Jianquan Zhang

ENHANCEMENT AND EVALUATION OF VARDENAFIL HYDROCHLORIDE TRIHYDRATE ABSORPTION IN ORODISPERSIBLE FORMULATION: ESTABLISHMENT OF IN VITRO , IN VIVO CORRELATION AND BIOEQUIVALENCE STUDY.

Pub Date : 2025-09-11 DOI: 10.1016/j.cbi.2025.111745 Kok Zheng Gan, Riyanto Teguh Widodo, Zamri Chik, Muhammad Luqman Nordin, Liew Kai Bin