American journal of physiology. Renal physiology

5-hydroxytryptamine 1F receptor loss reduces renal vasculature and prevents lasmiditan-induced recovery following moderate-severe acute kidney injury in mice.

Pub Date : 2025-10-08 DOI: 10.1152/ajprenal.00307.2025 Austin D Thompson, Kai W McAlister, Natalie E Scholpa, Jaroslav Janda, John Hortareas, Teodora G Georgieva, Rick G Schnellmann

Pregnane X receptor (PXR) increases urine concentration by upregulating hypothalamic arginine vasopressin expression.

Pub Date : 2025-10-06 DOI: 10.1152/ajprenal.00187.2025 Xiaowan Sun, Ruifen Li, Zhilin Luan, Beibei Ma, Hu Xu, Taotao Luo, Yitong Hu, Wenqian Zhao, Rongfang Qiao, Chunxiu Du, Jiahui Cao, Hui Zhou, Yanlin Guo, Jin Zhong, Yufei Zhang, Bin Yang, Youfei Guan, Xiao-Yan Zhang

Decreased parietal epithelial cell density is linked to podocyte depletion and predictors of kidney disease progression in human kidneys.

Pub Date : 2025-10-06 DOI: 10.1152/ajprenal.00243.2025 Jenna T Ference-Salo, Christopher L O'Connor, Rajasree Menon, Edgar A Otto, Meghan Dailey, Markus Bitzer, Jeffrey A Beamish