Discovery of a tau-aggregate clearing compound that covalently targets P4HB

待确认 20 由 honey 发布于 2026/11/10 16:55:32

DOI:10.1016/j.chembiol.2025.09.006
作者：Louis P. Conway , Michelle A. Estrada , Weichao Li , Stephen Walker , Benjamin Mielich-Süss , Anurupa Shrestha , Matthew Townsend , Jürgen Korffmann , Greg Po
文献类型：期刊论文
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Elsevier

Abstract：The improper folding and aggregation of tau are linked to several neurodegenerative diseases affecting millions worldwide. However, the pathogenesis of tauopathies remains poorly understood,

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