LPS-enriched interaction drives spectrum conversion in antimicrobial peptides: Design and optimization of AA16 derivatives for targeting gram-negative bacteria

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DOI:10.1016/j.ejmech.2025.117462
作者：Wanyang Xiao , Ruize Sun , Jietao Lou , Yanyan Xu , Xiaokun Li , Kaiyun Xin , Weijie Lu , Chenhui Sun , Tianbao Chen , Yitian Gao , Di Wu
文献类型：期刊论文
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Elsevier

Abstract：The increasing prevalence of antibiotic-resistant Gram-negative bacteria necessitates the development of novel antimicrobial agents with targeted specificity. In this study, we designed and

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