Disruption of Ataxia-telangiectasia mutated kinase enhances radiation therapy efficacy in spatially-directed diffuse midline glioma models.

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DOI:10.1172/jci179395
作者：Avani Mangoli,Vennesa Valentine,Spencer Maingi,Sophie R Wu,Harrison Q Liu,Michael Aksu,Vaibhav Jain,Bronwen E Foreman,Joshua A Regal,Loren B Weidenhammer,Connor E Stewart,Maria E Guerra Garcia,Emily H
文献类型：期刊论文
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Journal of Clinical Investigation (JCI)

Abstract：Diffuse midline gliomas (DMGs) are lethal brain tumors characterized by p53-inactivating mutations and oncohistone H3.3K27M mutations that rewire the cellular response to genotoxic stress. W

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