VIPER-TACs leverage viral E3 ligases for disease-specific targeted protein degradation

已完结 10 由 YAJ 发布于 2026/6/22 9:31:57

DOI:10.1016/j.chembiol.2025.02.002
作者：Kyle Mangano , Robert G. Guenette , Spencer Hill , Shiqian Li , Jeffrey J. Liu , Cory M. Nadel , Suresh Archunan , Arghya Sadhukhan , Rajiv Kapoor , Seung
文献类型：期刊论文
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Elsevier

Abstract：In targeted protein degradation (TPD) a protein of interest is degraded by chemically induced proximity to an E3 ubiquitin ligase. One limitation of using TPD therapeutically is that most E3

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