Artificial intelligence-guided design of LNPs for in vivo targeted mRNA delivery via analysis of the spatial conformation of ionizable lipids.

已完结 10 由 yyw 发布于 2026/6/23 12:00:26

DOI:10.1038/s41551-026-01640-8
作者：Lin-Jia Su,Nan-Nan Wang,Rui Luo,Zi-Han Ji,Haiyan Gu,Chao Yang,Mo-Xi Xu,Juchen Zhang,Qinghua Chen,Meng-Zhen Yu,Chenglin Li,Kelong Fan,Lin Mei,Yuliang Zhao,Yi Wang,Yurui Gao,Hao Wang,Yao-Xin Lin
文献类型：期刊论文
补充材料：只需要正文

Nature

Abstract：Efficient mRNA delivery to specific tissues requires optimized ionizable lipids, yet the role of lipid spatial conformation in organ targeting and endosomal escape remains underexplored. Her

应助信息

9小时前

Book学术机器人

8b04b9c12d7011f1b9e434735aa3bc31.pdf 已采纳

9小时前

Book学术机器人

2026/6/23 12:00:26 Book学术AI机器人已找到文献并上传

2026/6/23 12:00:26 Book学术AI机器人收到请求，开始寻找文献

2026/6/23 12:00:26 已向机器人发送请求

9小时前

yyw 发布求助

上一个求助:其它数据库Naturally Fractured Carbonate Reservoir Characterization: A Case Study of a Mature High-Pour Point Oil Field in Hungary 下一个求助:其它数据库Vision-based pose estimation of space resident objects using deep learning: Design and testing