Identification of VVD-214/RO7589831, a Clinical-Stage, Covalent Allosteric Inhibitor of WRN Helicase for the Treatment of MSI-High Cancers

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DOI:10.1021/acs.jmedchem.5c01805
文献类型：期刊论文
补充材料：只需要正文
文献链接：https://doi.org/10.1021/acs.jmedchem.5c01805

American Chemical Society (ACS)

Abstract：Werner syndrome helicase (WRN) has emerged as a compelling therapeutic target for microsatellite instability-high (MSI-H) cancers, owing to its selective dependency on the helicase activity

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