Reactive metabolites in early drug development: predictive in vitro tools.

已完结 10 由 YAN 发布于 2026/3/12 15:09:43

DOI:10.2174/0929867321666141012175543
作者：Olavi Pelkonen,?Markku Pasanen,?Ari Tolonen,?Mikko Koskinen,?Jukka Hakkola,?Khaled Abass,?Jaana Laine,?Merja Hakkinen,?Risto Juvonen,?Seppo Auriola,?Markus Storvik,?Pasi Huuskonen,?Timo Rousu,?Maiju R
文献类型：期刊论文
补充材料：只需要正文

Bentham Science

Abstract：Drug metabolism can result in the formation of highly reactive metabolites that are known to play a role in toxicity resulting in a significant proportion of attrition during drug developmen

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