Bile acids activate cancer-associated fibroblasts and induce an immunosuppressive microenvironment in cholangiocarcinoma

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DOI:10.1016/j.ccell.2025.05.017
作者：Fan Huang, Zengli Liu, Yan Song, Ganyu Wang, Anda Shi, Tianli Chen, Shaohui Huang, Shuo Lian, Kangshuai Li, Yongchang Tang, Lijie Zheng, Guoli Sheng, Nuoqi Zhang, Fan Yang, Chang Pan, Weiqiang Jing, Z
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Elsevier

Abstract：Cholangiocarcinoma (CCA) is a highly lethal malignancy originating from the biliary tract and characterized with exposure to high levels of bile acids (BAs). Immunotherapies have demonstrate

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