An in situ engineered chimeric IL-2 receptor potentiates the tumoricidal activity of proinflammatory CAR macrophages in renal cell carcinoma

已完结 10 由 bobobo 发布于 2026/1/5 9:05:44

DOI:10.1038/s43018-025-00950-1
作者：Weiqiang Jing,?Maosen Han,?Ganyu Wang,?Zhichao Kong,?Xiaotian Zhao,?Zhipeng Fu,?Xuewen Jiang,?Chongdeng Shi,?Chen Chen,?Jing Zhang,?Zuolin Zheng,?Jinxin Gao,?Weiyi Sun,?Chunwei Tang,?Zhenmei Yang,?Yan
文献类型：期刊论文
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Nature

Abstract：Chimeric antigen receptor macrophage (CAR-M) therapy has shown great promise in solid malignancies; however, the phenotypic re-domestication of CAR-Ms in the immunosuppressive tumor niche re

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