Copper induces cell death by targeting lipoylated TCA cycle proteins

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DOI:10.1126/science.abf0529
作者：Peter TsvetkovShannon CoyBoryana PetrovaMargaret DreishpoonAna VermaMai AbdusamadJohn K. EatonTodd R. GolubMustafa KocakEvgeni FrenkelSteven M. CorselloRanad HumeidiNaama KanarekSandro SantagataRyan D
文献类型：期刊论文
补充材料：只需要正文
文献链接：https://doi.org/10.1126/science.abf0529

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Abstract：Copper is an essential cofactor for all organisms, and yet it becomes toxic if concentrations exceed a threshold maintained by evolutionarily conserved homeostatic mechanisms. How excess cop

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