Branched chemically modified poly(A) tails enhance the translation capacity of mRNA

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DOI:10.1038/s41587-024-02174-7
作者：Hongyu Chen,&nbsp;Dangliang Liu,&nbsp;Jianting Guo,&nbsp;Abhishek Aditham,&nbsp;Yiming Zhou,&nbsp;Jiakun Tian,&nbsp;Shuchen Luo,&nbsp;Jingyi Ren,&nbsp;Alvin Hsu,&nb
文献类型：期刊论文
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Nature

Abstract：Although messenger RNA (mRNA) has proved effective as a vaccine, its potential as a general therapeutic modality is limited by its instability and low translation capacity. To increase the d

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