Discovery of 6,7-Dihydropyrazolo[1,5-a]pyrazin-4(5H)-one Derivatives as mGluR2 Negative Allosteric Modulators with In Vivo Activity in a Rodent’s Model of Cognition

已完结 10 由小小发布于 2025/4/18 9:03:06

DOI:10.1021/acs.jmedchem.4c01227
作者：Sergio A. Alonso de Diego, María Lourdes Linares, Aránzazu García Molina, Ana Isabel de Lucas, Alcira del Cerro, Jose Manuel Alonso, Luc Ver Donck, Jose María Cid, Andrés A. Trabanco, Michiel Van
文献类型：期刊论文
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American Chemical Society (ACS)

Abstract：Allosteric modulators of the metabotropic group II receptors, mGluR2 and mGluR3, have been widely explored due to their ability to modulate cognitive and neurological functions in mood disor

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