Enantioselective synthesis of 2-substituted bicyclo[1.1.1]pentanes via sequential asymmetric imine addition of bicyclo[1.1.0]butanes and skeletal editing

已完结 10 由 MKElpis 发布于 2025/5/1 22:04:24

DOI:10.1038/s41557-024-01710-x
作者：Jin-Teng Che, Wei-Yi Ding, Hong-Bo Zhang, Yong-Bin Wang, Shao-Hua Xiang, Bin Tan
文献类型：期刊论文
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Nature

Abstract：The substitution of an aromatic ring with a C(sp3)-rich bicyclic hydrocarbon, known as bioisosteric replacement, plays a crucial role in modern drug discovery. Substituted bicyclo[1.1.1]pent

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