Design, Synthesis, and Biological Evaluation of Novel Diaminopyrimidine Macrocycles as Fourth Generation Reversible EGFR Inhibitors That Overcome Clinical Resistance to Osimertinib Mediated by C797S Mutation

已完结 10 由小小发布于 2025/6/9 10:13:26

DOI:10.1021/acs.jmedchem.4c01975
作者：Shiliang Hu, Linjiang Tong, Qiao Qin, Jiaxin Wen, Yan Li, Fang Feng, Kunzhong Wu, Yang Zhou, Jinsai Shang, Junjian Wang, Jinbao Liu, Hua Xie, Xiaoyun Lu
文献类型：期刊论文
补充材料：只需要正文

American Chemical Society (ACS)

Abstract：Overcoming clinical resistance to osimertinib mediated by the tertiary C797S mutation remains an unmet medical need. To date, there are no effective drugs that have been approved for patient

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