Engineered Cas13 variants with minimal collateral RNA targeting

已取消 10 由 limi 发布于 2025/5/14 15:38:35

DOI:10.1038/s41587-022-01423-x
文献类型：期刊论文
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文献链接：https://doi.org/10.1038/s41587-022-01423-x
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Nature

Abstract：The application of CRISPR–Cas13 for targeted RNA degradation is hindered by the existence of collateral effects induced by Cas13. We screened hundreds of engineered Cas13 variants using a co

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