Direct cytosolic delivery of siRNA via cell membrane fusion using cholesterol-enriched exosomes

待确认 10 由 olinhuang1234 发布于 2026/7/12 22:04:48

DOI:10.1038/s41565-024-01785-0
作者：Yan Zhuo,?Zhen Luo,?Zhu Zhu,?Jie Wang,?Xiang Li,?Zhuan Zhang,?Cong Guo,?Bingqi Wang,?Di Nie,?Yong Gan,?Guoqing Hu,?Miaorong Yu
文献类型：期刊论文
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Nature

Abstract：Efficient cytosolic delivery is a significant hurdle when using short interfering RNA (siRNA) in therapeutic applications. Here we show that cholesterol-rich exosomes are prone to entering c

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