An in situ engineered chimeric IL-2 receptor potentiates the tumoricidal activity of proinflammatory CAR macrophages in renal cell carcinoma.

已完结 10 由 Direction92 发布于 2025/6/3 16:47:28

DOI:10.1038/s43018-025-00950-1
作者：Weiqiang Jing, Maosen Han, Ganyu Wang, Zhichao Kong, Xiaotian Zhao, Zhipeng Fu, Xuewen Jiang, Chongdeng Shi, Chen Chen, Jing Zhang, Zuolin Zheng,&nbsp
文献类型：期刊论文
补充材料：只需要正文

Nature

Abstract：Chimeric antigen receptor macrophage (CAR-M) therapy has shown great promise in solid malignancies; however, the phenotypic re-domestication of CAR-Ms in the immunosuppressive tumor niche re

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