Second-Generation Atroposelective Synthesis of KRAS G12C Covalent Inhibitor GDC-6036

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DOI:10.1021/acs.orglett.3c00961
文献类型：期刊论文
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文献链接：https://doi.org/10.1021/acs.orglett.3c00961

American Chemical Society (ACS)

Abstract：A chromatography-free asymmetric synthesis of GDC-6036 (1) was achieved via a highly atroposelective Negishi coupling of aminopyridine 5 and quinazoline 6b catalyzed by 0.5 mol % [Pd(cin)Cl]

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