Development of a Mild and Efficient Process for Ir-Catalyzed N-Alkylation of 4-Bromopyridin-2-amine with a Primary Alcohol via Borrowing Hydrogen

已完结 10 由 musgs 发布于 2024/12/24 11:18:14

DOI:10.1021/acs.oprd.4c00269
作者：Sri Krishna Nimmagadda, Srinivas Kalidindi, Siva Sankar Bondigela, Satish Korapati, Debottam Dasgupta, Noormohamed Abdul Malik, Prakasa Rao, Prantik Maity, John R. Coombs, Michael Hay, Eric M. Simmons
文献类型：期刊论文
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American Chemical Society (ACS)

Abstract：We report herein the development and scale up of an Ir-catalyzed N-alkylation reaction between a 4-bromopyridin-2-amine (1) and (4-(5-(1,1-difluoroethyl)-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]o

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