Optimization of the activity and biodegradability of ionizable lipids for mRNA delivery via directed chemical evolution

已完结 10 由 KK 发布于 2024/11/27 11:08:05

DOI:10.1038/s41551-024-01267-7
作者：Xuexiang Han, Mohamad-Gabriel Alameh, Ying Xu, Rohan Palanki, Rakan El-Mayta, Garima Dwivedi, Kelsey L. Swingle, Junchao Xu, Ningqiang Gong, Lulu Xue, Qiangqiang Shi, Il-Chul Yoon, Claude C. Warzecha,
文献类型：期刊论文
补充材料：只需要正文
文献链接：https://doi.org/10.1038/s41551-024-01267-7

Nature

Abstract：Ionizable lipids largely determine the biocompatibility of lipid nanoparticles (LNPs) and the efficacy for mRNA delivery. Rational design and combinatorial synthesis have led to the developm

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