AARS1 and AARS2 sense l-lactate to regulate cGAS as global lysine lactyltransferases

已完结 10 由 MR.G 发布于 2024/10/13 23:53:11

DOI:10.1038/s41586-024-07992-y
作者：Heyu Li, Chao Liu, Ran Li, Lili Zhou, Yu Ran, Qiqing Yang, Huizhe Huang, Huasong Lu, Hai Song, Bing Yang, Heng Ru, Shixian Lin, Long Zhang
文献类型：期刊论文
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Nature

Abstract：l-lactate modifies proteins through lactylation1, but how this process occurs is unclear. Here we identify the alanyl-tRNA synthetases AARS1 and AARS2 (AARS1/2) as intracellular l-lactate se

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