The Fanconi anemia pathway induces chromothripsis and ecDNA-driven cancer drug resistance

求助中 10 由 CCC 发布于 2024/11/5 15:36:48

DOI:10.1016/j.cell.2024.08.001
作者：Justin L. Engel, Xiao Zhang, Mingming Wu, Yan Wang, Jose Espejo Valle-Inclán, Qing Hu, Kidist S. Woldehawariat, Mathijs A. Sanders, Agata Smogorzewska, Jin Chen, Isidro Cortés-Ciriano, Roger S. Lo,
文献类型：期刊论文
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Elsevier

Abstract：Chromothripsis describes the catastrophic shattering of mis-segregated chromosomes trapped within micronuclei. Although micronuclei accumulate DNA double-strand breaks and replication defect

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