Design of Novel Exatecan-Amide Linker-Payloads for the Development of Stable, Low-Aggregating, and Highly Efficacious Antibody-Drug Conjugates

已完结 20 由 sz 发布于 2026/5/1 9:18:04

DOI:10.1021/acs.jmedchem.5c03706
作者：Ryan V. Quiroz, Simon B. Lang, Rebecca E. Johnson, Nancy Zepeda, Vlad Bacauanu, Christian L. Morales, Manoj Charati, John A. Flygare, Olivia R. Chastain, Zhong L. Hua, Edward P. Bowman, Bernhard H. Ge
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Abstract：Through their uniquely effective combination of a target-selective antibody and a highly potent cytotoxic payload, antibody-drug conjugates (ADCs) are transforming cancer therapy. Nonetheles

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