Discovery of Novel N-Linked Camptothecin Linker-Payloads to Access Antibody–Drug Conjugates with High Target-Mediated In Vivo Efficacy

已完结 20 由 sz 发布于 2026/5/1 9:18:30

DOI:10.1021/acs.jmedchem.5c03693
作者：Vlad Bacauanu, Si-Jie Chen, Simon B. Lang, Christian L. Morales, Nancy Zepeda, Manoj Charati, John A. Flygare, Rebecca E. Johnson, Ryan V. Quiroz, Song Yang, Olivia R. Chastain, Zhong L. Hua, Edward P
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Abstract：Antibody–drug conjugates (ADCs) are transforming oncology by enabling targeted delivery of potent cytotoxic agents to tumors. However, challenges such as resistance and limited response to e

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